Positive regulation of protein kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN4, UBE3A, and TMEM199, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPAN4 grouped by Positive regulation of protein kinase activity-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TSPAN4 →	+2.036	+0.210	<.001	.002	3	4
LIVER	UBE3A →	+0.489	+0.450	.009	.001	3	4
URINARY_TRACT	TMEM199 →	+0.602	+0.237	.003	.003	3	4
BREAST	ACO2 →	+0.579	+0.153	.003	.004	3	4
BREAST	CHN1 →	-2.382	-0.250	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	POU2F3 →	-0.714	-0.177	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPAN4 by Positive regulation of protein kinase activity activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →