Positive regulation of protein kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein kinase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JADE1, TLCD4-RWDD3, and RBM47, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JADE1 grouped by Positive regulation of protein kinase activity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	JADE1 →	-0.186	-1.320	.003	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	TLCD4-RWDD3 →	-0.156	-1.198	.008	<.001	3	3
BREAST	RBM47 →	+0.239	+0.337	.002	.009	3	3
BLOOD_Myeloma	ENPEP →	+0.395	+0.592	.003	<.001	3	3
BLOOD_Myeloma	BTAF1 →	-0.272	-0.406	.009	.006	1	5
LUNG_SCLC	TMEM209 →	+0.294	+0.226	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JADE1 by Positive regulation of protein kinase activity activity — KIDNEY

Explore this box plot interactively →