Positive regulation of protein kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFOD1, FUT3, and NSF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein kinase activity activity versus GFOD1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GFOD1 →	-1.618	-1.558	.005	<.001	3	4
URINARY_TRACT	FUT3 →	-3.860	-1.693	<.001	<.001	3	3
BLOOD_Leukemia	NSF →	+0.616	+0.133	.002	.003	3	3
LARGE_INTESTINE	SLC35A2 →	-0.622	-0.641	.001	.003	2	4
LARGE_INTESTINE	C3orf38 →	-0.379	-0.635	.008	.002	3	3
BLOOD_Leukemia	QRICH1 →	+0.528	+0.165	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045860 vs GFOD1 — UPPER_AERODIGESTIVE_TRACT

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