PH reduction

Across TCGA patient cohorts, RNA activity of the PH reduction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB8, PSME1, and SERPINB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, PH reduction activity versus PSMB8 in GBM (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSMB8 →	+0.291	+0.172	<.001	<.001	3	6
LUAD	PSME1 →	+0.269	+0.110	.005	.005	3	6
GBM	SERPINB1 →	+0.460	+0.176	<.001	<.001	3	6
GBM	VASP →	+0.485	+0.227	<.001	<.001	3	6
GBM	IKZF1_S63 →	+0.702	+0.209	.002	<.001	3	6
LSCC	BRF1 →	-0.190	-0.077	.004	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045851 vs PSMB8 — GBM

Explore this scatter interactively →