Positive regulation of mitotic nuclear division

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic nuclear division pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C4BPB, DYSF, and LOXL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic nuclear division activity versus C4BPB in OV (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C4BPB →	+0.540	+0.038	<.001	<.001	3	6
LSCC	DYSF →	+0.522	+0.047	<.001	.003	3	6
OV	LOXL2 →	+0.617	+0.047	.003	<.001	3	6
OV	PLOD2 →	+0.736	+0.057	.004	.001	2	7
BRCA	CAMP →	+1.156	+0.045	<.001	<.001	3	6
BRCA	ERCC6L_S1028 →	+1.054	+0.055	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045840 vs C4BPB — OV

Explore this scatter interactively →