Positive regulation of mitotic nuclear division

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMP5, ABCA6, and ABCC9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic nuclear division activity versus LAMP5 in BRCA (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LAMP5 →	-0.902	-0.705	.001	.001	3	6
GBM	ABCA6 →	-0.936	-0.624	<.001	.001	3	6
OV	ABCC9 →	-0.786	-0.697	.007	.001	3	6
GBM	MYBL2 →	+1.442	+0.689	<.001	<.001	3	6
GBM	DIAPH3 →	+0.945	+0.580	<.001	<.001	3	6
GBM	CDC25C →	+0.990	+0.545	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045840 vs LAMP5 — BRCA

Explore this scatter interactively →