Positive regulation of mitotic nuclear division

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic nuclear division pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANAPC5, CDC23, and CEACAM4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANAPC5 grouped by Positive regulation of mitotic nuclear division-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ANAPC5 →	-0.558	-0.286	.006	.005	2	7
PANCREAS	CDC23 →	-0.378	-0.356	<.001	<.001	3	6
PANCREAS	CEACAM4 →	-0.147	-0.248	.002	.004	3	4
LUNG_SCLC	CCAR1 →	-0.302	-0.260	.005	.003	2	5
LARGE_INTESTINE	AURKA →	-0.198	-0.203	.002	.004	3	4
CNS	PDE10A →	+0.135	+0.151	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANAPC5 by Positive regulation of mitotic nuclear division activity — STOMACH

Explore this box plot interactively →