Positive regulation of mitotic nuclear division

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRTAP2-3, CD274, and ABHD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KRTAP2-3 grouped by Positive regulation of mitotic nuclear division-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRTAP2-3 →	+2.906	+0.288	.002	.001	3	5
BREAST	CD274 →	+1.340	+0.152	.002	.003	3	5
KIDNEY	ABHD4 →	+1.550	+0.325	.003	.005	2	5
BREAST	VSIR →	+1.804	+0.153	.002	.008	3	4
OVARY	FHL2 →	+1.993	+0.208	.001	.003	3	4
OVARY	MT2A →	+2.296	+0.165	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRTAP2-3 by Positive regulation of mitotic nuclear division activity — OVARY

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