Positive regulation of membrane potential

Across TCGA cell cohorts, RNA activity of the Positive regulation of membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INSIG2, IRAK2, and IFRD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INSIG2 grouped by Positive regulation of membrane potential-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	INSIG2 →	+0.908	+0.202	.002	.006	2	5
BREAST	IRAK2 →	+1.649	+0.222	.005	.003	3	4
LARGE_INTESTINE	IFRD2 →	+0.488	+0.222	<.001	<.001	3	4
OESOPHAGUS	MT2A →	+2.202	+0.190	<.001	<.001	3	4
BONE	PTPRJ →	+2.637	+0.237	.005	.007	3	4
KIDNEY	SIPA1 →	+1.068	+0.200	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INSIG2 by Positive regulation of membrane potential activity — PANCREAS

Explore this box plot interactively →