Positive regulation of membrane potential

Across TCGA cell cohorts, RNA activity of the Positive regulation of membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NNT, LARGE1, and SLC25A25, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of membrane potential activity versus NNT in OESOPHAGUS (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NNT →	+2.508	+0.303	<.001	<.001	3	8
BLOOD_Lymphoma	LARGE1 →	+1.476	+0.265	.002	<.001	3	5
URINARY_TRACT	SLC25A25 →	+1.319	+0.231	.001	.003	3	5
LUNG_NSCLC_LUAD	GLRX →	+1.726	+0.203	<.001	<.001	3	4
LUNG_NSCLC_LUAD	LPCAT2 →	-1.331	-0.212	.002	.006	3	4
CNS	PRPS1 →	+0.767	+0.293	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045838 vs NNT — OESOPHAGUS

Explore this scatter interactively →