Negative regulation of meiotic nuclear division

Across TCGA cell cohorts, RNA activity of the Negative regulation of meiotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTC1, MRPL34, and ZNF514, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTC1 grouped by Negative regulation of meiotic nuclear division-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CTC1 →	+1.232	+0.310	.002	.005	3	4
BLOOD_Leukemia	MRPL34 →	-0.668	-0.221	.001	.004	3	3
BLOOD_Leukemia	ZNF514 →	+0.913	+0.244	<.001	<.001	3	3
BLOOD_Lymphoma	SLC16A7 →	+0.637	+0.310	.001	.005	3	3
OVARY	SCML2 →	-0.959	-0.157	<.001	.001	3	3
LIVER	ZCCHC3 →	-1.109	-0.266	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTC1 by Negative regulation of meiotic nuclear division activity — BLOOD_Lymphoma

Explore this box plot interactively →