Positive regulation of isotype switching

Across TCGA patient cohorts, RNA activity of the Positive regulation of isotype switching pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL7, and HCLS1_S275, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of isotype switching activity versus RPL5 in BRCA (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.203	-0.037	<.001	<.001	3	5
BRCA	RPL7 →	-0.253	-0.025	.001	.002	3	5
GBM	HCLS1_S275 →	+0.550	+0.059	<.001	<.001	3	5
BRCA	MAPKAPK2 →	+0.268	+0.025	.002	.003	3	5
GBM	NFATC2 →	+0.319	+0.042	<.001	<.001	3	5
HNSC	SASH3_S97 →	+0.664	+0.048	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045830 vs RPL5 — BRCA

Explore this scatter interactively →