Positive regulation of isotype switching

Across TCGA cell cohorts, RNA activity of the Positive regulation of isotype switching pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KMT5C, LUC7L2, and PAXIP1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of isotype switching activity versus KMT5C in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KMT5C →	+0.941	+0.047	.003	.005	3	14
SOFT_TISSUE	LUC7L2 →	+0.754	+0.080	<.001	.001	3	12
BONE	PAXIP1 →	+1.083	+0.102	<.001	<.001	2	13
BLOOD_Myeloma	XRCC2 →	+1.256	+0.071	.003	<.001	3	12
LIVER	PMS2 →	+0.932	+0.111	<.001	.002	3	12
KIDNEY	UBN2 →	+0.655	+0.100	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045830 vs KMT5C — UPPER_AERODIGESTIVE_TRACT

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