Positive regulation of isotype switching

Across TCGA cell cohorts, RNA activity of the Positive regulation of isotype switching pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5MC1, CSNK1G1, and USP11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of isotype switching activity versus ATP5MC1 in LARGE_INTESTINE (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATP5MC1 →	-0.576	-0.144	.009	.002	3	5
BREAST	CSNK1G1 →	+0.558	+0.195	.003	<.001	3	5
STOMACH	USP11 →	+1.131	+0.185	.004	.003	3	4
STOMACH	FAM72D →	+0.934	+0.263	.002	<.001	3	4
CNS	PTK7 →	+1.423	+0.182	.005	.009	3	4
BLOOD_Leukemia	BRPF3 →	+0.729	+0.146	.009	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045830 vs ATP5MC1 — LARGE_INTESTINE

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