Negative regulation of innate immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of innate immune response pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1, THEMIS2_T593, and TRIM21, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of innate immune response activity versus STAT1 in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT1 →	+0.759	+0.074	<.001	<.001	3	10
CCRCC	THEMIS2_T593 →	+0.776	+0.056	<.001	<.001	3	10
GBM	TRIM21 →	+0.392	+0.048	<.001	<.001	3	10
GBM	CMPK2 →	+0.826	+0.066	<.001	<.001	3	10
LSCC	DOCK10 →	+0.461	+0.060	<.001	<.001	3	10
GBM	AIF1 →	+0.676	+0.044	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045824 vs STAT1 — UCEC

Explore this scatter interactively →