Negative regulation of innate immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of innate immune response pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYM1, APOD, and ZNF219, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of innate immune response activity versus PYM1 in STOMACH (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PYM1 →	-1.212	-0.230	.001	<.001	3	6
BREAST	APOD →	-3.587	-0.187	.001	<.001	3	5
STOMACH	ZNF219 →	-2.230	-0.267	<.001	.007	3	5
STOMACH	PLEKHH1 →	-1.580	-0.261	.008	.008	3	5
URINARY_TRACT	MCAM →	+4.656	+0.405	<.001	.003	3	5
BREAST	GLIPR2 →	+1.922	+0.173	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045824 vs PYM1 — STOMACH

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