Positive regulation of glycolytic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of glycolytic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF106_S1370, SFXN3, and PDE4DIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glycolytic process activity versus ZNF106_S1370 in PDAC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ZNF106_S1370 →	-0.264	-0.032	.003	.004	3	4
LSCC	SFXN3 →	+0.433	+0.053	<.001	<.001	3	4
CCRCC	PDE4DIP →	+0.148	+0.038	<.001	<.001	3	4
COAD	TACC2 →	-0.202	-0.027	<.001	<.001	3	4
UCEC	SPATS2L_S159 →	+0.628	+0.063	.005	.002	3	3
LSCC	UBE2O_S411 →	-0.475	-0.090	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045821 vs ZNF106_S1370 — PDAC

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