Positive regulation of glycolytic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of glycolytic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A4, LDHAL6EP, and KLF15, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glycolytic process activity versus SLC4A4 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC4A4 →	+1.651	+0.888	<.001	<.001	3	8
GBM	LDHAL6EP →	+1.282	+0.416	<.001	<.001	3	6
CCRCC	KLF15 →	+1.112	+0.495	.001	.003	3	6
BRCA	ERBB4 →	+1.697	+0.917	<.001	<.001	3	6
LUAD	ABCD3 →	+0.393	+0.646	<.001	<.001	3	5
PDAC	KCNJ16 →	+1.334	+0.943	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045821 vs SLC4A4 — UCEC

Explore this scatter interactively →