Negative regulation of glycolytic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of glycolytic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAB2, ZNF451, and COLGALT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glycolytic process activity versus DAB2 in GBM (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DAB2 →	+0.506	+0.050	<.001	<.001	3	4
GBM	ZNF451 →	-0.281	-0.069	.001	<.001	3	4
GBM	COLGALT1 →	+0.377	+0.050	<.001	<.001	3	4
LSCC	C1R →	+0.474	+0.052	.001	.001	3	4
GBM	FOSL2_S200 →	+0.428	+0.056	<.001	<.001	3	4
OV	GRIP1_S847 →	+0.960	+0.042	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045820 vs DAB2 — GBM

Explore this scatter interactively →