Negative regulation of glycolytic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of glycolytic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED9, ELP5, and MRM3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glycolytic process activity versus MED9 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MED9 →	+0.352	+0.629	.004	.002	2	7
BRCA	ELP5 →	+0.503	+0.741	<.001	<.001	3	4
BRCA	MRM3 →	+0.396	+0.545	<.001	<.001	3	4
BRCA	TMEM256 →	+0.736	+0.686	<.001	.002	3	4
LSCC	TRA2B →	+0.535	+0.178	.007	.002	3	4
LSCC	LARP1B →	+0.338	+0.156	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045820 vs MED9 — BRCA

Explore this scatter interactively →