Negative regulation of glycolytic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of glycolytic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYNC2I2, RMND1, and CCNE2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DYNC2I2 grouped by Negative regulation of glycolytic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DYNC2I2 →	-0.898	-1.287	<.001	.008	2	6
URINARY_TRACT	RMND1 →	-0.811	-0.310	.002	.008	3	5
LIVER	CCNE2 →	-1.180	-0.346	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CYP20A1 →	-0.918	-0.304	.005	.001	3	4
UPPER_AERODIGESTIVE_TRACT	STIL →	-1.620	-0.345	.009	.007	3	4
UPPER_AERODIGESTIVE_TRACT	FAM204A →	-0.723	-0.258	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DYNC2I2 by Negative regulation of glycolytic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →