Negative regulation of glycolytic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of glycolytic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF4B, RPUSD4, and THAP9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glycolytic process activity versus TAF4B in BLOOD_Lymphoma (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TAF4B →	+1.373	+0.912	.001	.008	3	5
PANCREAS	RPUSD4 →	+0.734	+1.044	.001	.009	2	6
LARGE_INTESTINE	THAP9 →	+0.633	+0.774	.001	.006	3	5
LUNG_SCLC	PPARGC1B →	+0.822	+0.505	.005	.006	3	5
BLOOD_Lymphoma	CYFIP2 →	+1.947	+1.035	.004	.006	2	5
BLOOD_Lymphoma	WDR76 →	+1.329	+1.082	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045820 vs TAF4B — BLOOD_Lymphoma

Explore this scatter interactively →