Transcription initiation-coupled chromatin remodeling

Across TCGA patient cohorts, RNA activity of the Transcription initiation-coupled chromatin remodeling pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGTA1, GPAT3, and AQP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation-coupled chromatin remodeling activity versus GGTA1 in COAD (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GGTA1 →	-0.488	-0.120	<.001	.004	3	5
UCEC	GPAT3 →	-0.688	-0.230	.002	<.001	3	5
UCEC	AQP1 →	-0.738	-0.189	.003	.005	3	5
BRCA	SFI1 →	+0.717	+0.198	<.001	.003	3	5
GBM	KRTCAP2 →	+0.280	+0.303	<.001	.002	3	5
GBM	UBXN7-AS1 →	+0.350	+0.405	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045815 vs GGTA1 — COAD

Explore this scatter interactively →