Transcription initiation-coupled chromatin remodeling

Across TCGA cell cohorts, RNA activity of the Transcription initiation-coupled chromatin remodeling pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADRA2C, BCL7A, and MZB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADRA2C grouped by Transcription initiation-coupled chromatin remodeling-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ADRA2C →	+1.739	+0.224	.001	.002	3	5
LIVER	BCL7A →	+1.414	+0.392	<.001	.002	3	5
PANCREAS	MZB1 →	-0.478	-0.310	<.001	<.001	3	5
OVARY	MVP →	-2.033	-0.378	.001	<.001	3	4
OESOPHAGUS	CHST10 →	+1.404	+0.180	.004	.007	3	4
OESOPHAGUS	SALL2 →	+1.987	+0.241	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADRA2C by Transcription initiation-coupled chromatin remodeling activity — SOFT_TISSUE

Explore this box plot interactively →