Transcription initiation-coupled chromatin remodeling

Across TCGA cell cohorts, RNA activity of the Transcription initiation-coupled chromatin remodeling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX5, MFSD14C, and SACS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation-coupled chromatin remodeling activity versus DDX5 in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DDX5 →	+0.540	+0.111	.001	.001	3	5
LUNG_SCLC	MFSD14C →	+0.810	+0.192	<.001	<.001	3	5
LARGE_INTESTINE	SACS →	+1.116	+0.127	.003	.003	3	5
LUNG_NSCLC_LUSC	HLA-E →	-1.974	-0.225	.006	.006	3	4
PANCREAS	TYK2 →	+0.629	+0.119	<.001	.007	3	4
PANCREAS	LHPP →	-1.474	-0.159	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045815 vs DDX5 — BLOOD_Leukemia

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