"Negative regulation of gene expression, epigenetic"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of gene expression, epigenetic" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPYSL2, WBP4, and GPALPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPYSL2 grouped by "Negative regulation of gene expression, epigenetic"-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DPYSL2 →	-1.537	-0.139	.001	.003	3	6
PANCREAS	WBP4 →	-0.750	-0.201	<.001	.006	2	6
OVARY	GPALPP1 →	-0.653	-0.152	.003	.001	3	5
PANCREAS	ADAM9 →	-1.386	-0.152	<.001	.008	3	5
PANCREAS	ANKRD18A →	-1.255	-0.268	.009	.005	3	5
OVARY	NOTCH3 →	+2.262	+0.142	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPYSL2 by "Negative regulation of gene expression, epigenetic" activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →