"Negative regulation of gene expression, epigenetic"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of gene expression, epigenetic" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3-3A, LUC7L, and CBX2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of gene expression, epigenetic" activity versus H3-3A in STOMACH (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	H3-3A →	+1.013	+0.157	.003	.003	3	7
BLOOD_Leukemia	LUC7L →	+0.684	+0.142	<.001	<.001	3	6
SOFT_TISSUE	CBX2 →	+2.637	+0.213	.005	<.001	3	6
LUNG_SCLC	CENPF →	+1.133	+0.186	<.001	<.001	3	6
LUNG_NSCLC_LUSC	SLC30A7 →	-0.705	-0.154	.004	.008	3	5
BLOOD_Leukemia	UBE2T →	+0.802	+0.112	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045814 vs H3-3A — STOMACH

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