Positive regulation of endocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMN1, XPA, and DOCK6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FMN1 grouped by Positive regulation of endocytosis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FMN1 →	+1.837	+0.152	.001	.008	3	4
PANCREAS	XPA →	-0.483	-0.124	.006	.006	3	4
LUNG_SCLC	DOCK6 →	-1.101	-0.206	.002	<.001	3	3
BLOOD_Leukemia	IL13RA1 →	-1.655	-0.119	<.001	.005	3	3
URINARY_TRACT	LRRC70 →	+0.226	+0.245	<.001	.002	3	3
LARGE_INTESTINE	HDAC6 →	+0.970	+0.165	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FMN1 by Positive regulation of endocytosis activity — BLOOD_Myeloma

Explore this box plot interactively →