Positive regulation of endocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLUH, TWNK, and ZNFX1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endocytosis activity versus CLUH in OVARY (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CLUH →	-1.392	-0.342	<.001	<.001	3	8
BONE	TWNK →	-0.985	-0.357	.003	.007	3	7
LIVER	ZNFX1 →	+1.268	+0.281	<.001	.002	3	7
LIVER	PEBP1 →	-0.962	-0.143	.006	.002	3	7
SOFT_TISSUE	SRSF7 →	-0.712	-0.195	.007	.003	3	7
BONE	CAST →	+1.940	+0.416	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045807 vs CLUH — OVARY

Explore this scatter interactively →