Negative regulation of endocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of endocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC1, RAPGEF1, and PTPN12, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAC1 grouped by Negative regulation of endocytosis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RAC1 →	-0.364	-0.235	.001	.001	3	8
LUNG_NSCLC_LUAD	RAPGEF1 →	-0.367	-0.395	<.001	.006	3	5
BLOOD_Myeloma	PTPN12 →	+0.292	+1.586	<.001	.004	3	5
BLOOD_Myeloma	ITGAV →	-0.652	-1.542	<.001	.008	2	6
LUNG_NSCLC_LUAD	RASL11B →	+0.172	+0.204	<.001	.009	3	4
BLOOD_Myeloma	IGF2BP3 →	+0.540	+1.628	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAC1 by Negative regulation of endocytosis activity — URINARY_TRACT

Explore this box plot interactively →