Negative regulation of endocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAT14, ZSCAN2, and CEP19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KAT14 grouped by Negative regulation of endocytosis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KAT14 →	+1.031	+1.450	.002	.002	3	3
BLOOD_Myeloma	ZSCAN2 →	+0.791	+1.127	.001	.003	3	3
STOMACH	CEP19 →	-0.866	-0.211	.001	.008	2	4
BONE	POLR3A →	-0.439	-1.779	.002	<.001	3	3
BREAST	ATP6V0E2 →	-1.241	-0.572	<.001	.001	3	3
LARGE_INTESTINE	HAGHL →	-1.587	-0.171	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KAT14 by Negative regulation of endocytosis activity — BLOOD_Myeloma

Explore this box plot interactively →