Negative regulation of endocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASAL2, HLA-C, and ANXA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endocytosis activity versus RASAL2 in LIVER (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RASAL2 →	+0.782	+0.344	<.001	.004	3	7
CNS	HLA-C →	+2.355	+0.277	.007	.004	3	7
STOMACH	ANXA2 →	+2.570	+0.229	.002	.001	2	8
CNS	LAMP1 →	+0.890	+0.243	.002	.008	3	7
LARGE_INTESTINE	PXDC1 →	+1.434	+0.144	.003	.001	3	6
BLOOD_Lymphoma	OPTN →	+3.239	+0.238	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045806 vs RASAL2 — LIVER

Explore this scatter interactively →