Negative regulation of cell volume

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell volume pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TTI1, DKC1_S21, and ITPR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell volume activity versus TTI1 in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TTI1 →	-0.251	-0.081	<.001	.001	3	6
LUAD	DKC1_S21 →	-0.475	-0.049	.002	.001	3	5
GBM	ITPR1 →	+0.296	+0.057	.001	.007	3	5
GBM	CLTB →	+0.328	+0.069	<.001	<.001	3	4
GBM	PDE2A →	+0.780	+0.074	<.001	<.001	3	4
UCEC	RASIP1_S41 →	+0.460	+0.076	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045794 vs TTI1 — GBM

Explore this scatter interactively →