Negative regulation of cell volume

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell volume pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHANK3_S1570, SHANK3, and TNS2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell volume activity versus SHANK3_S1570 in CCRCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SHANK3_S1570 →	+0.829	+0.632	<.001	<.001	3	10
OV	SHANK3 →	+1.065	+0.524	<.001	.001	3	8
UCEC	TNS2 →	+0.454	+0.296	<.001	.001	3	7
CCRCC	CD34 →	+0.692	+0.735	<.001	<.001	3	7
CCRCC	KANK3 →	+0.695	+0.808	<.001	<.001	3	7
CCRCC	RASIP1 →	+0.524	+0.829	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045794 vs SHANK3_S1570 — CCRCC

Explore this scatter interactively →