Negative regulation of cell volume

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell volume pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCN3, P2RX7, and MAP3K5, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLCN3 grouped by Negative regulation of cell volume-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CLCN3 →	-0.313	-1.851	<.001	<.001	3	14
LUNG_SCLC	P2RX7 →	-0.411	-1.613	<.001	<.001	3	14
CNS	MAP3K5 →	+0.249	+1.135	.007	.009	3	5
CNS	KCNMA1 →	-0.231	-1.313	<.001	<.001	3	5
LARGE_INTESTINE	POP4 →	-0.301	-1.133	.006	.004	3	4
LUNG_NSCLC_LUSC	IPP →	+0.126	+1.588	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLCN3 by Negative regulation of cell volume activity — LUNG_SCLC

Explore this box plot interactively →