Positive regulation of cell size

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell size pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SALL4, ITGA11, and LINC01614, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell size activity versus SALL4 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SALL4 →	+0.862	+0.404	<.001	.001	3	3
LSCC	ITGA11 →	+0.591	+0.190	.002	<.001	3	3
LSCC	LINC01614 →	+0.964	+0.229	.003	.001	3	3
LSCC	LINC02126 →	+0.219	+0.172	.003	.009	2	4
COAD	MAP10 →	+0.481	+0.181	.005	.008	3	2
COAD	SCOCP1 →	+0.319	+0.176	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045793 vs SALL4 — HNSC

Explore this scatter interactively →