Negative regulation of cell size

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell size pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTIF3, MRPL38, and NME2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTIF3 grouped by Negative regulation of cell size-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MTIF3 →	+0.493	+1.362	.006	.009	3	3
SKIN	MRPL38 →	-0.544	-0.943	<.001	.002	3	3
SKIN	NME2 →	-0.343	-0.869	.001	.004	3	3
STOMACH	MINDY4 →	+1.285	+1.279	.009	.008	3	3
STOMACH	EIF3A →	+0.493	+1.141	.004	.004	3	3
STOMACH	DNAH6 →	+1.095	+1.337	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTIF3 by Negative regulation of cell size activity — BLOOD_Myeloma

Explore this box plot interactively →