Negative regulation of cell size

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell size pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMD1, NIPSNAP2, and FTH1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell size activity versus LIMD1 in BREAST (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LIMD1 →	+0.959	+1.715	.001	<.001	3	1
BREAST	NIPSNAP2 →	+1.563	+1.775	.006	<.001	3	1
BREAST	FTH1 →	+1.843	+1.644	.003	<.001	2	2
BREAST	FAM153A →	-0.173	-1.644	.001	<.001	3	1
BREAST	FZD8 →	+2.325	+1.668	.001	.001	3	1
BREAST	ARIH2 →	+0.743	+1.644	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045792 vs LIMD1 — BREAST

Explore this scatter interactively →