Positive regulation of bone resorption

Across TCGA patient cohorts, RNA activity of the Positive regulation of bone resorption pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDCD10, NRP2, and ICAM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of bone resorption activity versus PDCD10 in BRCA (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDCD10 →	+0.246	+0.034	<.001	<.001	3	6
CCRCC	NRP2 →	+0.614	+0.071	<.001	<.001	3	6
GBM	ICAM1 →	+0.717	+0.073	<.001	<.001	3	5
GBM	CTBP2 →	-0.317	-0.081	<.001	<.001	3	5
CCRCC	DDAH1 →	-0.395	-0.051	<.001	<.001	3	5
BRCA	IGF2BP2 →	+0.560	+0.031	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045780 vs PDCD10 — BRCA

Explore this scatter interactively →