Positive regulation of bone resorption

Across TCGA cell cohorts, RNA activity of the Positive regulation of bone resorption pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC5, CHRNA3, and PKHD1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXOSC5 grouped by Positive regulation of bone resorption-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EXOSC5 →	-0.570	-2.138	.009	.001	3	2
BLOOD_Leukemia	CHRNA3 →	+0.315	+2.069	.001	.006	3	2
SKIN	PKHD1 →	+0.212	+2.092	.006	<.001	3	2
SKIN	MMP7 →	-0.172	-2.092	<.001	<.001	3	2
SKIN	HS2ST1 →	-0.336	-2.138	.002	.001	3	2
SKIN	MAGEA8 →	+0.212	+2.143	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXOSC5 by Positive regulation of bone resorption activity — SKIN

Explore this box plot interactively →