Positive regulation of bone resorption

Across TCGA cell cohorts, RNA activity of the Positive regulation of bone resorption pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM8B, HIBCH, and CCNE1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of bone resorption activity versus TMEM8B in SKIN (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM8B →	+1.185	+2.092	<.001	<.001	3	3
BLOOD_Leukemia	HIBCH →	-0.540	-0.808	.001	.007	3	2
BLOOD_Leukemia	CCNE1 →	+1.141	+0.857	<.001	.003	3	2
BLOOD_Leukemia	TRIM38 →	+0.861	+1.059	.004	.009	3	2
SKIN	XYLT1 →	+3.597	+2.092	.001	<.001	3	2
SKIN	SLC29A1 →	-1.274	-2.092	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045780 vs TMEM8B — SKIN

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