Positive regulation of ossification

Across TCGA cell cohorts, RNA activity of the Positive regulation of ossification pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA1, ZNF490, and SULT1C2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTA1 grouped by Positive regulation of ossification-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ACTA1 →	+0.129	+0.673	.003	.002	3	3
LUNG_NSCLC_LUAD	ZNF490 →	+0.116	+0.878	.004	.001	2	4
LUNG_NSCLC_LUAD	SULT1C2 →	-0.168	-0.919	.007	.002	3	3
SOFT_TISSUE	CD48 →	+0.216	+1.514	.009	.003	2	4
KIDNEY	KCNIP2 →	+0.192	+1.801	.006	<.001	3	3
KIDNEY	LEFTY2 →	+0.230	+1.314	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTA1 by Positive regulation of ossification activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →