Positive regulation of ossification

Across TCGA cell cohorts, RNA activity of the Positive regulation of ossification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASIP, RIC8B, and TIMM17A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ossification activity versus ASIP in BLOOD_Leukemia (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASIP →	+0.263	+0.460	.001	.006	3	4
BLOOD_Leukemia	RIC8B →	+0.796	+0.596	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TIMM17A →	+0.554	+0.827	.001	<.001	3	3
LARGE_INTESTINE	PPP1CC →	+0.541	+0.585	.001	.008	2	4
KIDNEY	RPS26 →	+0.986	+1.428	.009	<.001	3	3
BLOOD_Leukemia	MRPL42 →	+0.649	+0.676	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045778 vs ASIP — BLOOD_Leukemia

Explore this scatter interactively →