Negative regulation of blood pressure

Across TCGA cell cohorts, RNA activity of the Negative regulation of blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIR, RPUSD4, and SLC26A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of blood pressure activity versus PIR in CNS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PIR →	+1.368	+0.229	<.001	<.001	3	4
KIDNEY	RPUSD4 →	-0.602	-0.220	.001	<.001	3	4
LUNG_SCLC	SLC26A2 →	+1.428	+0.233	.007	.003	3	4
LIVER	ACBD7 →	-1.385	-0.273	<.001	.002	3	4
LUNG_NSCLC_LUSC	DHX32 →	+1.345	+0.210	<.001	.005	3	4
PANCREAS	ERP29 →	+0.768	+0.788	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045776 vs PIR — CNS

Explore this scatter interactively →