Positive regulation of axon extension

Across TCGA cell cohorts, RNA activity of the Positive regulation of axon extension pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRIN3A, ZNF706, and TRMT6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRIN3A grouped by Positive regulation of axon extension-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRIN3A →	+0.107	+0.261	<.001	.005	3	5
URINARY_TRACT	ZNF706 →	-1.529	-0.562	<.001	.005	3	4
STOMACH	TRMT6 →	+0.575	+0.233	.003	.006	3	4
LUNG_NSCLC_LUSC	SDAD1 →	-0.676	-0.246	<.001	<.001	3	4
OVARY	LAMC1 →	-1.415	-1.042	.001	.002	3	3
LARGE_INTESTINE	CD160 →	+0.266	+0.264	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRIN3A by Positive regulation of axon extension activity — LARGE_INTESTINE

Explore this box plot interactively →