Positive regulation of adenylate cyclase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of adenylate cyclase activity pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K1, CD7, and PLCG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of adenylate cyclase activity activity versus MAP4K1 in COAD (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MAP4K1 →	-0.669	-0.647	<.001	.001	3	4
BRCA	CD7 →	-0.801	-0.452	.005	.003	3	4
GBM	PLCG2 →	-0.544	-0.190	<.001	.002	3	4
BRCA	LINC02613 →	-0.726	-0.448	<.001	.001	3	4
GBM	JAK3 →	-0.826	-0.188	<.001	<.001	3	4
LUAD	ACTR10 →	+0.350	+0.460	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045762 vs MAP4K1 — COAD

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