Positive regulation of adenylate cyclase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of adenylate cyclase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STIM1, ARNTL, and TLCD4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of adenylate cyclase activity activity versus STIM1 in BLOOD_Myeloma (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	STIM1 →	+1.406	+0.347	.006	.001	3	9
OVARY	ARNTL →	+0.806	+0.218	.004	.003	3	5
OVARY	TLCD4 →	+1.528	+0.265	.006	.002	3	5
OVARY	GRAMD2B →	+2.038	+0.337	.004	.001	3	5
OVARY	LAMP2 →	+0.929	+0.350	<.001	<.001	3	5
STOMACH	SCLY →	-0.976	-0.286	.005	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045762 vs STIM1 — BLOOD_Myeloma

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