Positive regulation of action potential

Across TCGA patient cohorts, RNA activity of the Positive regulation of action potential pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC9A1, SH3RF2, and KLHDC7A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of action potential activity versus SLC9A1 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC9A1 →	+1.000	+0.826	<.001	<.001	3	6
BRCA	SH3RF2 →	+0.790	+0.701	<.001	<.001	3	5
BRCA	KLHDC7A →	+1.313	+0.758	<.001	<.001	3	4
CCRCC	PTPRH →	+0.836	+0.632	.004	.002	3	4
LUAD	RHBDL2 →	+0.464	+0.274	.003	.001	2	5
LUAD	SIDT1-AS1 →	+0.487	+0.226	.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045760 vs SLC9A1 — BRCA

Explore this scatter interactively →