Positive regulation of Notch signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of Notch signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FN1, MAP1A, and SRPX2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Notch signaling pathway activity versus FN1 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FN1 →	+0.610	+0.030	<.001	.004	3	8
GBM	MAP1A →	+0.525	+0.054	<.001	<.001	3	8
BRCA	SRPX2 →	+0.712	+0.033	<.001	<.001	3	7
CCRCC	SSC5D →	+0.580	+0.054	<.001	<.001	3	7
CCRCC	ACTN1 →	+0.444	+0.058	<.001	<.001	3	7
CCRCC	COL1A1 →	+0.936	+0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045747 vs FN1 — BRCA

Explore this scatter interactively →