Negative regulation of Notch signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of Notch signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKDC, PPP1R12B, and RRP9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Notch signaling pathway activity versus PRKDC in BRCA (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKDC →	-0.235	-0.031	.002	.003	3	5
CCRCC	PPP1R12B →	+0.520	+0.044	<.001	<.001	3	5
GBM	RRP9 →	-0.305	-0.045	<.001	<.001	3	5
GBM	COLGALT1 →	-0.531	-0.048	<.001	<.001	3	5
GBM	RFC2 →	-0.271	-0.032	<.001	.003	3	5
CCRCC	APOA2 →	+0.538	+0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045746 vs PRKDC — BRCA

Explore this scatter interactively →